Scientific Publications

First Evaluation of the 4D-PET, a dedicated brain PET based on semi monolithic scintillator crystal detectors. 

L. Moliner, C. Correcher, A. Beltrá, J. Álamo, J. Barberá, C. Morera-Ballester, K. Diaz, D. Sánchez, A. Mondejar, E. Muñoz, A. Lucero, S. Jiménez-Serrano, I. Torres, M. Gandía, A. Penades, J.O. Prior, J.M. Benlloch

submitted to Scientific Reports on 29 March 2024.

First Results of the 4D-PET Brain System.

A. Gonzalez-Montoro, J. Barberá, A. Lucero, A. Mondejar, K. Diaz, S. Jimenez-Serrano, D. Sánchez, A. Laing, M. Freire, C. Morera-Ballester, J. Alamo, L. Moliner, V. Ilisie, A.J. Gonzalez, J. Prior and J.M. Benlloch

submitted to TRPMS-2023-0200.R1 

First Results of the 4D-PET Brain System.

A. Gonzalez-Montoro, J. Barberá, A. Lucero, A. Mondejar, K. Diaz, S. Jimenez-Serrano, D. Sánchez, A. Laing, M. Freire, C. Morera-Ballester, J. Alamo, L. Moliner, V. Ilisie, A.J. Gonzalez, J. Prior and J.M. Benlloch

2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD) Vancouver, BC, Canada, 2023, pp. 1-2,

Doi: 10.1109/NSSMICRTSD49126.2023.10337911
https://ieeexplore.ieee.org/document/10337911/metrics

Preclinical PET scanner with timing and 3D capabilities based on semi-monolithic crystals.

Cucarella, N.; Freire, M.;Valladares, C.; Barrio, J.; Gonzalez A.J.; Bruyndonckx, P.; Correcher, C.; Benlloch J.M.,

2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD)

Doi: 10.1109/NSSMICRTSD49126.2023.10338640
https://ieeexplore.ieee.org/document/10338640

Semi-monolithic meta-scintillator simulation proof- of-concept, combining accurate DOI and TOF.

G. Konstantinou, L. Zhang, D. Bonifacio, R. Latella, J.M. Benlloch, A.J. Gonzalez, and P. Lecoq 

TechRxiv. April 29, 2023.
Doi: https://doi.org/10.36227/techrxiv.22708045.v1

Analytical modeling of the sensitivity of cylindrical PET systems based on bulk materials and metascintillators.

D.A.B. Bonifacio, R. Latella, H. Massaharu Murata, J.M. Benlloch, A. Gonzalez, P. Lecoq, G. Konstantinou

TechRxiv. April 19, 2023.
Doi: https://doi.org/10.36227/techrxiv.22637731.v1

Modeling brain-dedicated PET systems using metascintillators for optimized ToF capability.

D.A.B. Bonifacio, R. Latella, H. Massaharu Murata , J.M. Benlloch, A. Gonzalez , P. Lecoq, G. Konstantinou

TechRxiv. July 20, 2023.
Doi: 10.36227/techrxiv.23699694.v1

A proof-of-concept of cross-luminescent metascintillators: testing results on a BGO:BaF2 metapixel.

 Konstantinou, G.; Latella, R.; Moliner, L.; Zhang, L.; Benlloch J.M., Gonzalez A.J.; and Lecoq, P.

Physics in Medicine and Biology, 68 (2023) 025018

Doi: 10.1088/1361-6560/acac5f

https://iopscience.iop.org/article/10.1088/1361-6560/acac5f/pdf

Exploiting Cherenkov radiation with BGO-based metascintillators.

Latella, R.; Gonzalez A.J.; Bonifacio, D.A.B.; Kovylina, M.; Griol, A.; Benlloch J.M., Lecoq, P.; Konstantinou, G.

IEEE Trans. Rad. Plasma Med. Scie. 7, 810, 2023

Doi: 10.36227/techrxiv.21388863.v1

https://ieeexplore.ieee.org/document/10236492

A new brain dedicated PET scanner with 4D detector information.

Gonzalez-Montoro, A., Barbera, J.; Sanchez, D.; Mondejar, A.; Freire, M.; Diaz, K.; Lucero, A.; Jimenez-Serrano, S.; Alamo, J.; Morera-Ballester, C.; Barrio, J.; Cucarella, N.; Ilisie, V.; Moliner, L.; Valladares, C.; Gonzalez A.J.; Prior J. and Benlloch J.M.,

Bio-Algorithms and Med-Systems 2022; 18(1): 107-119

Doi: 10.2478/bioal-2022-0083

https://riunet.upv.es/handle/10251/194867

Experimental validation of a rodent PET scanner prototype based on a single LYSO crystal tube.

M. Freire; A. Gonzalez-Montoro; G. Cañizares; A. Rezaei; J. Nuyts; S. S. Berr; M. B. Williams; J. M. Benlloch; A. González

IEEE Transactions on Radiation and Plasma Medical Sciences, vol. 6, no. 6, pp. 697-706, July 2022, 

Doi: 10.1109/TRPMS.2021.3124448.

https://ieeexplore.ieee.org/document/9596579 

Metascintillators: New Results for TOF-PET Applications.

Lecoq, P.; Konstantinou, G.; Latella, R. Moliner, L.; Nuyts J.; Zhang, L.; Barrio,J.; Benlloch J.M.,  and Gonzalez A.J.;

IEEE Trans. Rad. Plasma Med. Scie. 6, 510, 2022

Doi: 10.1109/trpms.2022.3161473

https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9740339

Architecture-Level Optimization on Digital Silicon Photomultipliers for Medical Imaging.

Bandi, F.; Ilisie, V.; Vornicu, I.; Carmona-Galán, R.; Benlloch J.M; and Rodríguez-Vázquez, A.

Sensors 2022, 22, 122. 

https://doi.org/10.3390/s22010122

Evaluation of Crystal Arrays for Accurate Positioning and Timing PET detectors.

Valladares, C.; Lamprou, E.; Gonzalez A.J.; Barrio, J.; Cucarella, N.; Freire, M.; Vidal, L.F.; and Benlloch J.M.,

2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: 10.1109/NSS/MIC44867.2021.9875558

2D Feasibility study of joint reconstruction of attenuation and activity in limited angle TOF-PET. 

Vergara M, Rezaei A, Schramm G, Rodriguez-Alvarez MJ, Benlloch Baviera JM, Nuyts J.

IEEE Trans Radiat Plasma Med Sci. 2021 Sep;5(5):712-722. 

Doi: 10.1109/trpms.2021.3079462. Epub 2021 May 12. PMID: 34541435; PMCID: PMC8445242.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445242/pdf/nihms-1737570.pdf

Simulation Study of a Frame-Based Motion Correction Algorithm for Positron Emission Imaging.

H. Espinós-Morató, D. Cascales-Picó, M. Vergara, A. Hernández-Martínez, J.M. Benlloch Baviera and M.J. Rodríguez-Álvarez 

Sensors 2021, 21, 2608. 

https://doi.org/10.3390/s21082608

Timing evaluation of a PET detector block based on semi-monolithic LYSO crystals.

Cucarella, N.; Barrio, J.; Lamprou, E.; Valladares, C.; Benlloch J.M., Gonzalez A.J.;

Medical Physics 48, 8010, 2021

Doi: 10.1002/mp.15318

https://aapm.onlinelibrary.wiley.com/doi/10.1002/mp.15318

Gamma Camera Imaging with Rotating Multi-Pinhole Collimator. A Monte Carlo Feasibility Study.

Ilisie, V.; Moliner, L.; Constantino Morera, Johan Nuyts, Benlloch J.M.,

Sensors 2021, 21, 3367

Doi: 10.3390/s21103367

https://www.mdpi.com/1424-8220/21/10/3367

Metascintillators for ultra-fast gamma detectors: a review of current state and future perspectives.

G. Konstantinou, P. Lecoq, J.M. Benlloch, Gonzalez A.J.

IEEE Trans. Rad. Plasma Med. Scie. 6, 5, 2021

Doi: 10.1109/trpms.2021.3069624

https://ieeexplore.ieee.org/document/9394412

PET Detector based on a Semi-Monolithic Crystal with DOI and TOF Capabilities.

Barrio, J.; Cucarella, N.;Freire, M.; Lamprou, E.; Aguilar, A.; Valladares, C.; Ilisie, V.; Benlloch J.M., and Gonzalez A.J.;

2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: https://doi.org/10.1109/nss/mic42677.2020.9508047

A novel metascintillator approach for ultra-fast timing in Positron Emission Tomography.

Konstantinou, G.; Barrio, J.; Moliner, L.; Gabriel Cañizares, Cucarella, N.; Benlloch J.M.; Lecoq, P.; Gonzalez A.J.;

2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: https://ieeexplore.ieee.org/document/9508015

Towards 100 ps PET Detectors Suitable for High-Resolution Brain Mouse Imaging.

Lamprou, E.; Valladares, C.; Barrio, J.; Cucarella, N.; Aguilar, S.; Cañizares, G.; Freire, M.; Echegoyen, S.; Sanchez, F.; Vidal, L.F.; Hernadez, L.; Mascarell, A.; Benlloch J.M., and Gonzalez A.J.;

2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: https://ieeexplore.ieee.org/document/9507997

Simulation Study for Designing a Dedicated Cardiac TOF-PET System.

S. Oliver, L. Moliner, V. Ilisie, J.M. Benlloch and M.J. Rodríguez-Álvarez 

Sensors 2020, 20(5), 1311.

https://doi.org/10.3390/s20051311

Roadmap toward the 10 ps time-of-flight PET challenge.

P. Lecoq, Ch. Morel, J.O. Prior, D. Visvikis, S. Gundacker, E. Auffray, P. Križan, R.R. Martinez Turtos, D. Thers, E. Charbon, J. Varela, Ch. de La Taille, A. Rivetti, D. Breton, J.-F. Pratte, J. Nuyts, S. Surti, S. Vandenberghe, P. Marsden, K. Parodi, J.M. Benlloch, M. Benoit.

2020 Phys. Med. Biol. 65 21RM01

Doi: 10.1088/1361-6560/ab9500

https://iopscience.iop.org/article/10.1088/1748-0221/12/11/C11027/pdf

Characterization of a High-Aspect Ratio Detector With Lateral Sides Readout for Compton PET.

Barrio, J.; Cucarella, N.; Gonzalez A.J.; Freire, M.; Ilisie, V.; Benlloch J.M., 

IEEE Trans. Rad. Plas. Med. Scie., 4, 546, 2020

Doi: 10.1109/trpms.2020.3006862

https://ieeexplore.ieee.org/document/9133201

In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC.

Lamprou, E.; Sanchez, F.; Jose M. Benlloch; Gonzalez A.J.

Nuclear Instruments and Methods A 977, 164295, 2020.

Doi: 10.1016/j.nima.2020.164295

https://www.sciencedirect.com/science/article/pii/S0168900220306914

Pilot performance of a dedicated prostate PET suitable for diagnosis and biopsy guidance.

Cañizares, G.; Gonzalez-Montoro, A.; Freire, M.; Lamprou, E.; Barrio, J.; Sanchez, F.; Benlloch J.M., Hernandez, L.; Moliner, L.; Vidal, L.F.; Torres, I.; Sopena, P.; Vera-Donoso, C.D.; Bello, P.; Barbera, J.; Gonzalez A.J.;

European Journal Nuclear Medicine and Molecular Imaging 7, 38, 2020.

Doi: 10.1186/s40658-020-00305-y

https://www.researchgate.net/publication/341949117_Pilot_performance_of_a_dedicated_prostate_PET_suitable_for_diagnosis_and_biopsy_guidance

Progress reports on the MEDAMI 2019 and CTR research at the DMIL in i3M.

Gonzalez A.J.; Barrio, J.; Lamprou, E.; Ilisie, V.; Sanchez, F.; Benlloch J.M.

Il Nuovo Cimento 43C (2020) 5.

Doi: 10.1393/ncc/i2020-20005-8

https://riunet.upv.es/handle/10251/164476

High resolution and sensitivity gamma camera with active septa. A first Monte Carlo study.

Ilisie, V.; Moliner, L.; Oliver, S.; Sánchez, F.; Gonzalez A.J.; Seimetz, M.; Rodríguez-Álvarez, M.J.; Benlloch J.M.

Scientific Reports 9, 18431, 2020

Doi: 10.1038/s41598-019-54934-0

https://www.nature.com/articles/s41598-019-54934-0

Calibration of Gamma Ray Impacts in Monolithic-Based Detectors Using Voronoi Diagrams.

Freire, M.; Gonzalez-Montoro, A.; Sanchez, F.; Jose M. Benlloch, Gonzalez A.J.

IEEE Trans. Rad. Plas. Med. Scie., 4, 350, 2020.

Doi: 10.1109/TRPMS.2019.2947716

https://ieeexplore.ieee.org/abstract/document/8871159

Characterization of LYSO and CeBr3 Detectors with Lateral Sides Readout for a Multilayer Compton-PET.

Barrio, J.; Cucarella, N.; Gonzalez A.J.; Aguilar, S.; Gonzalez-Montoro, A.; Ilisie, V.; Lamprou, E.; Sanchez, F.; Benlloch J.M.,

2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: 10.1109/nss/mic42101.2019.9059991

https://ieeexplore.ieee.org/document/9059991

TOF studies for dedicated PET with open geometries.

Moliner, L.; Ilisie, V.; Gonzalez-Montoro, A.; Oliver, S.; Gonzalez-Montoro, AGimenez-Alventosa, V.; Cañizares, G.; Lamprou, E.; Alamo, J.; Sanchez, F.; Rodriguez, M.J.; Benlloch J.M.,

Journal of Instruments 14, C02006, 2019

Doi: 10.1088/1748-0221/14/02/c02006

https://iopscience.iop.org/article/10.1088/1748-0221/14/02/C02006/meta

Exploring TOF Capabilities of PET Detector Blocks Based on Large Monolithic Crystals and Analog SiPMs.

Physica Medica 70, 10-18, 2019

Doi: 10.1016/j.ejmp.2019.12.004

https://pubmed.ncbi.nlm.nih.gov/31935602/

Novel method to measure the intrinsic spatial resolution in PET detectors based on monolithic crystals.

Gonzalez-Montoro, A.; Sanchez, F.; Bruyndonckx, P., Cañizares G.; Benlloch J.M., Gonzalez A.J.

Transaction on Nuclear Science, vol. 63, no 5, pp. 2487-2495, 2019 

Doi: 10.1016/j.nima.2018.12.056

https://www.sciencedirect.com/science/article/pii/S0168900218318539/pdfft?md5=1889af93f8dbbce45f283076ff77d7b7&pid=1-s2.0-S0168900218318539-main.pdf

Performance comparison of large-area SiPM arrays suitable for gamma ray detectors.

Gonzalez-Montoro, A.; Gonzalez A.J.

Biomed. Phys. Eng. Express 5 (2019) 045013

Doi: 10.1088/2057-1976/ab0f6e

https://iopscience.iop.org/article/10.1088/2057-1976/ab0f6e/pdf

Initial Results of the MINDView PET Insert Inside the 3T mMR.

Gonzalez A.J.; Gonzalez-Montoro, A.; Vidal, L.F.; Barbera, J.; Aussenhofer, S.; Hernandez, L; Moliner, L.; Sanchez, F.; Correcher, C.; Pincay, E.J.; Cañizares G.; Lamprou, E.; Sanchez, S.; Catret, J.V.; Jimenez-Serrano, S.; Cabello, J.; Schwaiger, M.; Iborra, A; Merlin, T.; Visvikis, D.; Benlloch J.M.

IEEE Trans. Rad. Plas. Med. Scie., 3, 343, 2019

Doi: 10.1109/trpms.2018.2866899

https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8444667

Calibration of PET Detectors Based on Monolithic Blocks Using Voronoi Diagrams.

Freire, M.; Gonzalez-Montoro, A.; Sanchez, F.; Gonzalez A.J.;

2018 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: 10.1109/NSSMIC.2018.8824291

https://ieeexplore.ieee.org/document/8824291

TOF-PET Detectors Based on ASIC Technology and Analog SiPMs.

Lamprou, E.; Gonzalez-Montoro, A.; Cañizares, G.; Ilisie, V.; Sánchez, F.; Freire, M.; Hernández, L.; Vidal, L.F.; Barrio, J.; Gonzalez A.J.; Benlloch J.M.,

2018 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: 10.1109/NSSMIC.2018.8824517

https://ieeexplore.ieee.org/abstract/document/8824517

Characterization of TOF-PET Detectors Based on Monolithic Blocks and ASIC-Readout.

Lamprou, E.; Gonzalez-Montoro, A.; Cañizares, G.; Ilisie, V.; Barrio, J.; Sanchez, F.; Gonzalez A.J.; Benlloch J.M.,

2018 arXiv:1806.08715 [physics.ins-det]

Doi: doi.org/10.48550/arXiv.1806.08715

Detector block performance based on a monolithic LYSO crystal using a novel signal multiplexing method.

Gonzalez-Montoro, A.; Sanchez, F.; Martí, R.; Hernandez, L;Aguilar, A.; Barberá, J.; Catret, J.V.; Cañizares G.; Conde, P.; Lamprou, E.; Martos, F., Sánchez, S.; Vidal, L.F.; Benlloch J.M., Gonzalez A.J.

Nuclear Instruments and Methods A 912, 372, 2018.

Doi: 10.1016/j.nima.2017.10.098

https://www.sciencedirect.com/science/article/pii/S0168900217311506/pdfft?md5=db4518944b6ad37282005a10af0b5c25&pid=1-s2.0-S0168900217311506-main.pdf

Organ-Dedicated Molecular Imaging Systems

Gonzalez A.J.; Sanchez, F.; and Benlloch J.M.

IEEE Trans. Rad. Plas. Med. Scie. 2, 388, 2018.

Doi: 10.1109/trpms.2018.2846745

https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8383996

Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube.

Gonzalez A.J.; Berr S.S., Cañizares G.; Gonzalez-Montoro, A.; Orero A; Correcher C; Rezaei A.; Nuyts J.; Sanchez F.; Majewski S. and Benlloch J.M. (2018). 

Front. Med. 5:328.

Doi: 10.3389/fmed.2018.00328

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279866/pdf/fmed-05-00328.pdf

Building blocks of a multi-layer PET with time sequence photon interaction discrimination and double Compton camera.

Ilisie, V.; Giménez-Alventosa, V.; Moliner, L.; Sánchez, F.; González, A.J.; Rodríguez-Álvarez, M.J.; Benlloch, J.M.

Nuclear Instruments and Methods A 895, 74-83, 2018.

Doi: 10.1016/j.nima.2018.03.076

https://www.sciencedirect.com/science/article/abs/pii/S0168900218304431

PET detector block with accurate 4D capabilities.

Lamprou, E.; Aguilar, A.; González-Montoro, A.; Monzó, J.M.; Cañizares G.; Iranzo, S.; Vidal, L.F.; Hernández, L.; Conde, P.; Sánchez, S.; Sánchez, F.; González, A.J.; Benlloch J.M.,

Nuclear Instruments and Methods A 912, 132, 2018.

Doi: 10.1016/j.nima.2017.11.002

https://www.sciencedirect.com/science/article/pii/S0168900217311889/pdfft?md5=ef66e3ca7420e4d38101e87cac1e05e7&pid=1-s2.0-S0168900217311889-main.pdf

Progress Report for an Accurate PET Detector Based on SiPMs and the TOFPET ASIC

Lamprou, E.; Aguilar, A.; Gonzalez-Montoro, A.; Monzo, J.M.; Canizares, G.; Vidal, L.F.; Hernandez, L.; Iranzo, S.; Marti, R.; Sanchez, S.; Sanchez, F.; Gonzalez A.J.; Benlloch J.M.,

2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: https://doi.org/10.1109/nssmic.2017.8533123

Improving PET Sensitivity and Resolution by Photon Interaction Sequence Timing Discrimination.

Ilisie, V.; Gimenez-Alventosa, V.; Moliner, L.; Aguilar, A.; Lamprou, E.; Gonzalez A.J.; Sanchez, F.; Benlloch J.M.,

2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Doi: 10.1109/nssmic.2017.8532644

https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8532644

Highly improved operation of monolithic BGO-PET blocks.

Gonzalez-Montoro, A.; Sanchez, F.; Majewski, S.; Zanettini, S.; Benlloch J.M., Gonzalez A.J.

Journal of Instrumentation, JINST 12 C11027, 2017

Doi: 10.1088/1748-0221/12/11/c11027

https://iopscience.iop.org/article/10.1088/1748-0221/12/11/C11027/pdf

A scintillator geometry suitable for very small PET gantries.

Gonzalez A.J.; Gonzalez-Montoro, A.; Aguilar, A.; Cañizares G.; Martí, R.; Iranzo, S.; Lamprou, E.; Sanchez, S.; Sanchez, F.; Benlloch J.M.

Journal of Instrumentation, JINST 12 C12018, 2017

Doi: 10.1088/1748-0221/12/12/c12018

https://iopscience.iop.org/article/10.1088/1748-0221/12/12/C12018/pdf

Improving PET sensitivity with a Compton algorithm.

Ilisie, V.; Giménez-Alventosa, V.; Moliner, L.; Aguilar, A.; Lamprou, E.; Gonzalez-Montoro, A.; Sánchez, F.; Benlloch, J.M.

J. Phys.: Conf. Ser. 931 012012. (2017)

https://iopscience.iop.org/article/10.1088/1742-6596/931/1/012012/pdf